Audiogenic epilepsy in mice with different genotypes after neonatal treatments enhancing neurogenesis in dentate gyrus

Bull Exp Biol Med. 2009 Apr;147(4):458-61. doi: 10.1007/s10517-009-0558-3.
[Article in English, Russian]

Abstract

Pups of Wistar and KM rats (with predisposition to audiogenic epilepsy) were daily injected with neuropeptide semax (50 mg/kg) or NO-synthase inhibitor L-NAME (50 mg/kg) on days 7-11 of life. Alterations of audiogenic seizures pattern were revealed in rats of both strains at the age of 1 month, while changes in seizure severity were genotype-dependent. Both agents enhance neurogenesis in the dentate gyrus of the hippocampus and the delayed effect in the form of altered seizure pattern seems to be determined by this factor. Genotype-dependent alterations of seizure severity after administration of semax and L-NAME were differently directed. These effects are suggested to be underlined by physiological and biochemical mechanisms not related to the intensity of postnatal neurogenesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenocorticotropic Hormone / analogs & derivatives
  • Adrenocorticotropic Hormone / pharmacology
  • Animals
  • Animals, Newborn
  • Dentate Gyrus / drug effects*
  • Dentate Gyrus / physiopathology
  • Enzyme Inhibitors / pharmacology
  • Epilepsy, Reflex / drug therapy*
  • Epilepsy, Reflex / genetics*
  • Female
  • Genotype*
  • Male
  • NG-Nitroarginine Methyl Ester / pharmacology
  • Neurogenesis / drug effects*
  • Neurogenesis / physiology
  • Neuroprotective Agents / pharmacology
  • Nitric Oxide Synthase / antagonists & inhibitors
  • Peptide Fragments / pharmacology
  • Rats
  • Rats, Wistar
  • Seizures / drug therapy
  • Seizures / genetics
  • Severity of Illness Index
  • Species Specificity
  • Time Factors

Substances

  • Enzyme Inhibitors
  • Neuroprotective Agents
  • Peptide Fragments
  • ACTH (4-7), Pro-Gly-Pro-
  • Adrenocorticotropic Hormone
  • Nitric Oxide Synthase
  • NG-Nitroarginine Methyl Ester