Pharmacokinetics of moxifloxacin in cerebrospinal fluid and plasma in patients with tuberculous meningitis

Clin Infect Dis. 2009 Oct 1;49(7):1080-2. doi: 10.1086/605576.

Abstract

Moxifloxacin cerebrospinal fluid (CSF) penetration was evaluated by obtaining full plasma and CSF time concentration curves for 4 patients with tuberculous meningitis. The geometric mean ratio of the areas under the curve for CSF to plasma were 0.82 (range, 0.70-0.94) at 400 mg once per day and 0.71 (0.58-0.84) at 800 mg once per day.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Antitubercular Agents / administration & dosage
  • Antitubercular Agents / pharmacokinetics*
  • Antitubercular Agents / therapeutic use*
  • Area Under Curve
  • Aza Compounds / administration & dosage
  • Aza Compounds / pharmacokinetics*
  • Aza Compounds / therapeutic use*
  • Cerebrospinal Fluid / chemistry*
  • Fluoroquinolones
  • Humans
  • Male
  • Middle Aged
  • Moxifloxacin
  • Plasma / chemistry*
  • Quinolines / administration & dosage
  • Quinolines / pharmacokinetics*
  • Quinolines / therapeutic use*
  • Time Factors
  • Tuberculosis, Meningeal / drug therapy*

Substances

  • Antitubercular Agents
  • Aza Compounds
  • Fluoroquinolones
  • Quinolines
  • Moxifloxacin