Abstract
Anti-oxidative effect of Phellinus linteus (P. linteus) and red ginseng extracts on DNA damage induced by reactive oxygen species (ROS) were investigated in this study. P. linteus (PLE) and red ginseng extracts (RGE) inhibited the breaking of E. coli ColE1 plasmid DNA strands as well as nuclear DNA of rat hepatocytes damaged by oxidative stress. In addition, a reaction mixture of PLE and RGE showed synergistic inhibitory effect against DNA damage. These results suggest that PLE and RGE have a cellular defensive effect against DNA damage induced by ROS.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antioxidants / pharmacology*
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Cell Nucleus / drug effects
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Cell Nucleus / metabolism
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DNA Breaks / drug effects
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DNA Damage*
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DNA, Bacterial / metabolism
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Eukaryotic Cells / drug effects
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Eukaryotic Cells / metabolism
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Ferrous Compounds / pharmacology
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Hepatocytes / drug effects
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Hepatocytes / metabolism
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Hydrogen Peroxide / pharmacology
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Oxidative Stress / drug effects*
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Panax / metabolism*
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Phellinus
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Plant Extracts / pharmacology*
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Plasmids / metabolism
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Polysaccharides / pharmacology*
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Rats
Substances
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Antioxidants
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DNA, Bacterial
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Ferrous Compounds
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Phellinus linteus extract
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Plant Extracts
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Polysaccharides
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Hydrogen Peroxide
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ferrous chloride