A first low-resolution difference Fourier map of phosphorus in a membrane protein from near-edge anomalous diffraction

J Synchrotron Radiat. 2009 Sep;16(Pt 5):658-65. doi: 10.1107/S0909049509025692. Epub 2009 Jul 8.

Abstract

Crystal diffraction of three membrane proteins (cytochrome bc(1) complex, sarcoplasmic reticulum Ca(2+) ATPase, ADP-ATP carrier) and of one nucleoprotein complex (leucyl tRNA synthetase bound to tRNAleu, leuRS:tRNAleu) was tested at wavelengths near the X-ray K-absorption edge of phosphorus using a new set-up for soft X-ray diffraction at the beamline ID01 of the ESRF. The best result was obtained from crystals of Ca(2+) ATPase [adenosin-5'-(beta,gamma-methylene) triphosphate complex] which diffracted out to 7 A resolution. Data were recorded at a wavelength at which the real resonant scattering factor of phosphorus reaches the extreme value of -20 electron units. The positions of the four triphosphates of the monoclinic unit cell of the ATPase have been obtained from a difference Fourier synthesis based on a limited set of anomalous diffraction data.

MeSH terms

  • Crystallography, X-Ray / methods*
  • Fourier Analysis
  • Membrane Proteins / chemistry*
  • Phosphorus / analysis*

Substances

  • Membrane Proteins
  • Phosphorus