Abstract
We enlarged the uniconazole (UNI) molecule to find a specific inhibitor of abscisic acid (ABA) 8'-hydroxylase, and synthesized various UNI derivatives that were substituted with hydrophilic and hydrophobic groups at the 4-chlorine of the phenyl group of UNI using click chemistry. Considering its potency in ABA 8'-hydroxylase inhibition, its small effect on seedling growth, and its ease of application, UT4, the UNI derivative containing the C4 alkyltriazole, was the best candidate for a highly selective inhibitor of ABA 8'-hydroxylase.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cytochrome P-450 Enzyme Inhibitors*
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Cytochrome P-450 Enzyme System / metabolism
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / chemistry*
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Enzyme Inhibitors / pharmacology
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Malus / growth & development
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Oryza / growth & development
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Plant Proteins
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Recombinant Proteins / antagonists & inhibitors
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Recombinant Proteins / metabolism
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Seedlings / drug effects
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Seedlings / growth & development
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Triazoles / chemical synthesis
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Triazoles / chemistry*
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Triazoles / pharmacology
Substances
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Cytochrome P-450 Enzyme Inhibitors
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Enzyme Inhibitors
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Plant Proteins
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Recombinant Proteins
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Triazoles
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Cytochrome P-450 Enzyme System
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abscisic acid 8'-hydroxylase
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uniconazole