PPACK-Desmodus rotundus salivary plasminogen activator (cDSPAalpha1) prevents the passage of tissue-type plasminogen activator (rt-PA) across the blood-brain barrier and neurotoxicity

Thromb Haemost. 2009 Sep;102(3):606-8. doi: 10.1160/TH09-02-0114.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biotinylation
  • Blood-Brain Barrier / metabolism*
  • Chiroptera
  • Fibrinolytic Agents / therapeutic use
  • Humans
  • Ischemia / therapy
  • Mice
  • Neurons / pathology*
  • Plasminogen Activators / metabolism*
  • Recombinant Proteins / therapeutic use
  • Stroke / therapy
  • Tissue Plasminogen Activator / metabolism*

Substances

  • Fibrinolytic Agents
  • Recombinant Proteins
  • salivary plasminogen activator alpha 1, Desmodus rotundus
  • Plasminogen Activators
  • Tissue Plasminogen Activator