Abstract
2-(4-Chloro-3-methylphenoxy)acetohydrazide (2) derived from ethyl 2-(4-chloro-3-methylphenoxy) acetate (1) was reacted with different aromatic aldehydes to yield N-(substituted benzylidiene)-2-(4-chloro-3-methylphenoxy)acetamide (3a-e). Cyclization of compound (3a-e) with thioglycolic acid yielded 2-(4-chloro-3-methylphenoxy)-N-(4-oxo-2-arylthiazolidin-3-yl) acetamide (4a-e). The newly synthesized compounds were characterized on the basis of spectral studies and evaluated for antibacterial and antifungal activities.
MeSH terms
-
Anti-Bacterial Agents / chemical synthesis
-
Anti-Bacterial Agents / pharmacology
-
Anti-Infective Agents / chemical synthesis*
-
Anti-Infective Agents / pharmacology*
-
Antifungal Agents / chemical synthesis
-
Antifungal Agents / pharmacology
-
Bacteria / drug effects
-
Fungi / drug effects
-
Imines / chemical synthesis*
-
Imines / pharmacology*
-
Indicators and Reagents
-
Magnetic Resonance Spectroscopy
-
Microbial Sensitivity Tests
-
Spectrophotometry, Infrared
-
Thiazolidines / chemical synthesis*
-
Thiazolidines / pharmacology*
Substances
-
Anti-Bacterial Agents
-
Anti-Infective Agents
-
Antifungal Agents
-
Imines
-
Indicators and Reagents
-
Thiazolidines