Abstract
New approaches to predicting ligand similarity and protein interactions can explain unexpected observations of drug inefficacy or side-effects.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Binding Sites
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Computational Biology
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Drug Design
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Drug Discovery
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Drug-Related Side Effects and Adverse Reactions / diagnosis*
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Drug-Related Side Effects and Adverse Reactions / metabolism
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Humans
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Pharmaceutical Preparations / chemistry*
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Pharmaceutical Preparations / metabolism
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Protein Interaction Mapping / methods*
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Protein Interaction Mapping / trends
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Systems Biology / methods*
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Systems Biology / trends
Substances
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Pharmaceutical Preparations