Antibodies to cerebellar soluble lectin CSL in multiple sclerosis

Lancet. 1990 Jun 23;335(8704):1482-4. doi: 10.1016/0140-6736(90)93027-m.

Abstract

Cerebrospinal fluid samples from 239 patients with various neurological disorders were tested for the presence of autoantibodies to an endogenous mannose-binding protein, the cerebellar soluble lectin CSL, by means of an immunoblotting test with rat CSL as antigen. 47 of 51 patients with multiple sclerosis were positive for anti-CSL compared with 30 of 188 patients with other neurological disorders. 14 of the 30 false-positive patients were over 60 years old, an age group not typical of multiple sclerosis patients. The specificity of the test for multiple sclerosis was 85% and the sensitivity 93.5%. The possibility that CSL is an important immunological target in multiple sclerosis allows new insights into the possible causes and development of this disorder.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Autoantibodies / cerebrospinal fluid*
  • Evaluation Studies as Topic
  • False Positive Reactions
  • Humans
  • Immunoblotting / methods
  • Lectins / immunology*
  • Middle Aged
  • Multiple Sclerosis / cerebrospinal fluid
  • Multiple Sclerosis / immunology*
  • Predictive Value of Tests

Substances

  • Autoantibodies
  • Lectins
  • cerebellar soluble lectin