The use of mitochondrial nutrients to improve the outcome of infertility treatment in older patients

Yaakov Bentov; Navid Esfandiari; Eliezer Burstein; Robert F Casper

doi:10.1016/j.fertnstert.2009.07.988

The use of mitochondrial nutrients to improve the outcome of infertility treatment in older patients

Fertil Steril. 2010 Jan;93(1):272-5. doi: 10.1016/j.fertnstert.2009.07.988. Epub 2009 Sep 3.

Authors

Yaakov Bentov¹, Navid Esfandiari, Eliezer Burstein, Robert F Casper

Affiliation

¹ Toronto Centre for Advanced Reproductive Technology, University of Toronto, Toronto, Ontario, Canada.

PMID: 19732879
DOI: 10.1016/j.fertnstert.2009.07.988

Abstract

We present a hypothesis emphasizing the role of mitochondrial dysfunction in reproductive senescence and suggesting the use of mitochondrial nutrients as an adjuvant treatment in older patients with infertility.

MeSH terms

Age Factors
Aging / metabolism
Animals
DNA, Mitochondrial / metabolism
Dietary Supplements*
Energy Metabolism / drug effects
Female
Humans
Infertility, Female / drug therapy*
Infertility, Female / genetics
Infertility, Female / metabolism
Mice
Mice, Inbred ICR
Mitochondria / drug effects*
Mitochondria / metabolism
Oocytes / drug effects*
Oocytes / metabolism
Pregnancy
Resveratrol
Stilbenes / pharmacology
Thioctic Acid / pharmacology
Ubiquinone / pharmacology*

Substances

DNA, Mitochondrial
Stilbenes
Ubiquinone
Thioctic Acid
Resveratrol