Objective: To investigate whether antipsychotic-induced weight gain was associated with adiponectin gene +45T/G and +276G/T polymorphism.
Methods: A case-matched study was done: 85 patients who gained more than 7% of their pre-drug body weight were designed to the study group and 85 patients who gained less than 7% of their pre-drug body weight served as the control group. Ligation diction reaction technique was used to analyze the frequencies of the +276G/T and +45T/G polymorphism of adiponectin gene.
Results: The presence of +276G allele was significantly higher in the study group as compared with the control group.
Conclusion: Subjects with the +276G variant alleles may have a greater risk for weight gain after antipsychotic treatment.