HLA-D region genomic polymorphism associated with Takayasu's arteritis

Angiology. 1990 Jun;41(6):421-6. doi: 10.1177/000331979004100601.

Abstract

Takayasu's arteritis, with a strong predilection for women and particular geographic areas, has revealed significant association with human lymphocyte antigens (HLA) specificities. In the present study, the authors investigated for the first time the association of Takayasu's arteritis and HLA at the genomic level. By use of a restriction endonuclease Taq-I and a DQA cDNA probe, HLA-D region restriction fragment length polymorphism was examined in 32 Japanese patients. It was revealed that 65.6% of the patients shared a 6.6 kb fragment, although this fragment was found in 35.3% of the healthy Japanese (Chi square: 6.07, p less than 0.02). This finding suggest that HLA-D region gene variations determine susceptibility to Takayasu's arteritis.

MeSH terms

  • Adult
  • Aortic Arch Syndromes / genetics*
  • DNA Probes
  • Female
  • Genes, MHC Class II*
  • HLA-DQ Antigens / genetics*
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Restriction Fragment Length
  • Takayasu Arteritis / genetics*

Substances

  • DNA Probes
  • HLA-DQ Antigens