Abstract
A convenient chemoenzymatic strategy for synthesizing sialosides containing a C5-diversified sialic acid was developed. The alpha2,3- and alpha2,6-linked sialosides containing a 5-azido neuraminic acid synthesized by a highly efficient one-pot three-enzyme approach were converted to C5''-amino sialosides, which were used as common intermediates for chemical parallel synthesis to quickly generate a series of sialosides containing various sialic acid forms.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Biocatalysis
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Glycosides / chemical synthesis*
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Glycosides / chemistry
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Glycosides / pharmacology
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N-Acetylneuraminic Acid / chemistry*
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N-Acylneuraminate Cytidylyltransferase / chemistry
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N-Acylneuraminate Cytidylyltransferase / metabolism
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Oxo-Acid-Lyases / chemistry
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Oxo-Acid-Lyases / metabolism
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Sialyltransferases / chemistry
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Sialyltransferases / metabolism
Substances
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Glycosides
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Sialyltransferases
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N-Acylneuraminate Cytidylyltransferase
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Oxo-Acid-Lyases
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N-acetylneuraminate lyase
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N-Acetylneuraminic Acid