Abstract
Proteolysis is used by all forms of life for shaping the proteome in response to adverse environmental conditions in order to ensure optimal survival. Here we will address the role of proteolysis in helping cells respond to environmental stress, with a focus on the impact of proteolysis under DNA-damaging conditions and in maintenance of cellular homeostasis in response to metal exposure in bacteria.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adenosine Triphosphatases / genetics
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Adenosine Triphosphatases / metabolism
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Bacterial Proteins / metabolism
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Biocatalysis
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DNA Damage
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism
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DNA-Directed DNA Polymerase / genetics
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DNA-Directed DNA Polymerase / metabolism
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Escherichia coli / enzymology*
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Escherichia coli / genetics
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Escherichia coli Proteins / genetics
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Escherichia coli Proteins / metabolism*
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Homeostasis / genetics
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Metals / metabolism*
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Metals / toxicity
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SOS Response, Genetics / genetics
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Serine Endopeptidases / metabolism
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Stress, Physiological
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Transcription Factors / metabolism
Substances
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Bacterial Proteins
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DNA-Binding Proteins
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Escherichia coli Proteins
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LexA protein, Bacteria
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Metals
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Transcription Factors
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ZntR protein, E coli
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DNA polymerase V, E coli
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DNA-Directed DNA Polymerase
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Serine Endopeptidases
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UvrA protein, E coli
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Adenosine Triphosphatases