Accurate assessment of intragenic recombination frequency within the Duchenne muscular dystrophy gene

S Abbs; R G Roberts; C G Mathew; D R Bentley; M Bobrow

doi:10.1016/0888-7543(90)90205-9

Accurate assessment of intragenic recombination frequency within the Duchenne muscular dystrophy gene

Genomics. 1990 Aug;7(4):602-6. doi: 10.1016/0888-7543(90)90205-9.

Authors

S Abbs¹, R G Roberts, C G Mathew, D R Bentley, M Bobrow

Affiliation

¹ Paediatric Research Unit, United Medical School Guy's Hospital, London, United Kingdom.

PMID: 1974880
DOI: 10.1016/0888-7543(90)90205-9

Abstract

Polymorphic loci that lie at the two extremities of the Duchenne/Becker muscular dystrophy (DMD/BMD) gene have been used to estimate intragenic recombination rates. Multipoint linkage analysis of the CEPH panel of families suggests a total intragenic recombination frequency of nearly 0.12 (confidence intervals 0.041-0.226) over the genomic length of approximately 2 Mb.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Genes
Genetic Linkage*
Humans
Introns*
Lod Score
Muscular Dystrophies / genetics*
Polymorphism, Restriction Fragment Length
Recombination, Genetic*