Reactive oxygen species scavenging activities and inhibition on DNA oxidative damage of dimeric compounds from the oxidation of (-)-epigallocatechin-3-O-gallate

Fitoterapia. 2010 Apr;81(3):205-9. doi: 10.1016/j.fitote.2009.09.004. Epub 2009 Sep 12.

Abstract

The dimeric catechins dehydrotheasinensin A (2) and theacitrin C (3) were prepared from the oxidation of (-)-epigallocatechin-3-O-gallate (EGCG, 1), and their antioxidant activity was investigated using a chemiluminescence (CL) method in vitro. Both compounds showed significant inhibitory effects on reactive oxygen species (O(2)(-), H(2)O(2) and *OH) and DNA oxidative damage, with 2 being more potent than 3 and EGCG itself.

MeSH terms

  • Antioxidants / metabolism
  • Antioxidants / pharmacology*
  • Camellia sinensis / chemistry*
  • Catechin / analogs & derivatives*
  • Catechin / chemistry
  • Catechin / isolation & purification
  • Catechin / metabolism
  • Catechin / pharmacology*
  • DNA Damage / drug effects*
  • Dimerization
  • Oxidation-Reduction / drug effects
  • Plant Extracts / chemistry
  • Plant Extracts / metabolism
  • Plant Extracts / pharmacology*
  • Plant Leaves
  • Reactive Oxygen Species / metabolism

Substances

  • Antioxidants
  • Plant Extracts
  • Reactive Oxygen Species
  • dehydrotheasinensin A
  • theacitrin C
  • Catechin