An ultrasensitive electrochemical "turn-on" label-free biosensor for Hg2+with AuNP-functionalized reporter DNA as a signal amplifier

Chem Commun (Camb). 2009 Oct 7:(37):5633-5. doi: 10.1039/b911163h. Epub 2009 Aug 5.

Abstract

A highly selective electrochemical biosensor for the ultrasensitive detection of Hg2+ in aqueous solution has been developed based on the strong and specific binding of Hg2+ by two DNA thymine bases (T-Hg2+-T) and the use of AuNP-functionalized reporter DNA to achieve signal amplification.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA / chemistry*
  • DNA, Catalytic / chemistry
  • Environmental Pollutants / analysis*
  • Gold / chemistry*
  • Mercury / analysis*
  • Metal Nanoparticles / chemistry*
  • Thymine / chemistry

Substances

  • DNA, Catalytic
  • Environmental Pollutants
  • Gold
  • DNA
  • Mercury
  • Thymine