Heptanosides from galactose-derived oxepenes via stereoselective addition reactions

J Org Chem. 2009 Oct 16;74(20):7627-32. doi: 10.1021/jo901706e.

Abstract

Addition reactions to a 3,4-anhydroheptanose gave heptanoside analogues of carbohydrate derivatives in good to excellent stereochemical purity. Characterization of the products by (1)H and (13)C NMR, COSY, HSQC-DEPT, HMBC, 1D TOCSY, and NOE experiments were performed to obtain the stereochemistry of addition. The 3,4-anhydroheptanose used in this study is obtained from the ring-expansion of a cyclopropanated galactal and thus demonstrates the synthetic utility of heptanose synthesis via cyclopropanated carbohydrates.

MeSH terms

  • Galactose / chemistry*
  • Heptoses / chemistry*
  • Molecular Structure
  • Oxepins / chemistry*
  • Stereoisomerism

Substances

  • Heptoses
  • Oxepins
  • Galactose