Abstract
Among other genes, expression of the Bcl-6 transcriptional repressor distinguishes follicular helper T (Tfh) cells from other helper T cell subsets. In this issue of Immunity, Yu et al. (2009) demonstrate that Bcl-6 directs Tfh cell differentiation.
MeSH terms
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Animals
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Cell Differentiation
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Cell Lineage*
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism*
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Gene Expression
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Humans
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Lymphoid Tissue / cytology*
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Mice
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Proto-Oncogene Proteins c-bcl-6
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T-Lymphocytes, Helper-Inducer / cytology*
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T-Lymphocytes, Helper-Inducer / immunology*
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T-Lymphocytes, Helper-Inducer / metabolism
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Transcription Factors / genetics
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Transcription Factors / metabolism*
Substances
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BCL6 protein, human
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Bcl6 protein, mouse
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DNA-Binding Proteins
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Proto-Oncogene Proteins c-bcl-6
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Transcription Factors