Abstract
A Helicobacter pylori mutant defective in a putative mfd gene was constructed and characterized. The mfd gene is required for DNA repair and is involved in DNA recombination processes. The mfd mutant strain displayed a greatly increased susceptibility to antibiotics, indicating that this gene plays a significant role in the antibiotic resistance of H. pylori strain J99.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Bacterial Proteins / physiology*
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Colony Count, Microbial
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DNA Repair*
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Drug Resistance, Bacterial*
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Gene Deletion
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Helicobacter pylori / drug effects*
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Helicobacter pylori / physiology*
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Microbial Sensitivity Tests
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Mitomycin / pharmacology
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Recombination, Genetic
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Transcription Factors / deficiency
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Transcription Factors / physiology*
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Transcription Factors
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transcription repair coupling factor protein, Bacteria
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Mitomycin