Abstract
A photoluminescent II-VI group semiconductor nanocrystal (NC)-based signaling platform composed of thioglycolic acid capped CdS NCs and acetylcholinesterase-acetylthiocholine enzyme catalytic reaction system was developed that was shown to be highly sensitive to nerve agents and toxic organophosphate pesticides with detection limits down to sub-nM levels. This new sensing protocol does not require troublesome conjugation of biomacromolecules onto the surface of NCs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Absorption
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Acetylcholine / chemistry
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Acetylcholine / metabolism
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Acetylcholinesterase / metabolism
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Biosensing Techniques / methods*
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Cadmium Compounds / chemistry
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Luminescent Measurements
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Nanoparticles / chemistry*
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Nervous System / drug effects*
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Organophosphates / analysis*
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Organophosphates / toxicity*
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Pesticides / analysis*
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Pesticides / toxicity*
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Sulfides / chemistry
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Thioglycolates / chemistry
Substances
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Cadmium Compounds
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Organophosphates
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Pesticides
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Sulfides
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Thioglycolates
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cadmium sulfide
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Acetylcholinesterase
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Acetylcholine