Abstract
Analogues of the 2-oxoglutarate cosubstrate of the human oxygen sensing enzyme prolyl hydroxylase domain 2 (PHD2) with variations in the potential iron-chelating group were screened as inhibitors and for binding (using non-denaturing electrospray ionization mass spectrometry) to PHD2.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Fluorescence Resonance Energy Transfer
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Humans
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Iron Chelating Agents
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Ketoglutaric Acids / chemistry*
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Ketoglutaric Acids / pharmacology
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Procollagen-Proline Dioxygenase / antagonists & inhibitors*
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Procollagen-Proline Dioxygenase / metabolism
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Protein Binding
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Protein Structure, Tertiary
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Spectrometry, Mass, Electrospray Ionization
Substances
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Iron Chelating Agents
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Ketoglutaric Acids
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Procollagen-Proline Dioxygenase