Straightforward synthesis of the near-infrared fluorescent voltage-sensitive dye RH1691 and analogues thereof

Raphaël Lebeuf; Isabelle Férézou; Jean Rossier; Stellios Arseniyadis; Janine Cossy

doi:10.1021/ol901846g

Straightforward synthesis of the near-infrared fluorescent voltage-sensitive dye RH1691 and analogues thereof

Org Lett. 2009 Nov 5;11(21):4822-5. doi: 10.1021/ol901846g.

Authors

Raphaël Lebeuf¹, Isabelle Férézou, Jean Rossier, Stellios Arseniyadis, Janine Cossy

Affiliation

¹ Laboratoire de Chimie Organique, ESPCI ParisTech, CNRS, 10 rue Vauquelin, 75231 Paris Cedex 05, France.

PMID: 19780571
DOI: 10.1021/ol901846g

Abstract

A highly straightforward synthesis of the near-infrared voltage-sensitive dye RH1691 is reported featuring two sequential anionic additions of C-nucleophilic heterocycles on a cyanine. This convergent approach led to the synthesis of four new probes, which also exhibit fluorescence in the near-infrared region.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Fluorescence
Fluorescent Dyes / chemical synthesis
Infrared Rays
Molecular Structure
Pyrazoles / chemical synthesis*
Pyrazoles / chemistry
Thiazoles / chemical synthesis*
Thiazoles / chemistry

Substances

Fluorescent Dyes
Pyrazoles
RH1691
Thiazoles