Antituberculosis activity of the molecular libraries screening center network library

Tuberculosis (Edinb). 2009 Sep;89(5):354-63. doi: 10.1016/j.tube.2009.07.006. Epub 2009 Sep 26.

Abstract

There is an urgent need for the discovery and development of new antitubercular agents that target novel biochemical pathways and treat drug-resistant forms of the disease. One approach to addressing this need is through high-throughput screening of drug-like small molecule libraries against the whole bacterium in order to identify a variety of new, active scaffolds that will stimulate additional biological research and drug discovery. Through the Molecular Libraries Screening Center Network, the NIAID Tuberculosis Antimicrobial Acquisition and Coordinating Facility tested a 215,110-compound library against Mycobacterium tuberculosis strain H37Rv. A medicinal chemistry survey of the results from the screening campaign is reported herein.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Antitubercular Agents / pharmacology*
  • Cluster Analysis
  • Drug Discovery*
  • Drug Evaluation, Preclinical*
  • Humans
  • Mycobacterium tuberculosis / drug effects*
  • Research
  • Small Molecule Libraries*
  • Tuberculosis / drug therapy*
  • Tuberculosis / genetics

Substances

  • Antitubercular Agents
  • Small Molecule Libraries