No association between high temperature requirement 1 (HTRA1) gene polymorphisms and Alzheimer's disease

Neurobiol Aging. 2011 Mar;32(3):547.e7-9. doi: 10.1016/j.neurobiolaging.2009.08.010. Epub 2009 Sep 23.

Abstract

High temperature requirement 1 (HTRA1) gene is a plausible risk factor in Alzheimer's disease (AD) as it encodes a protease known to degrade amyloid-β peptide. Here we have studied whether single nucleotide polymorphisms (SNPs) in the HTRA1 gene or its nearby regions associated with AD in a large clinic-based case-control cohort originating from Finland. We did not observe significant association of the HTRA1 SNPs with AD among the whole case-control cohort or age-at-onset risk effect among AD patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / genetics*
  • Case-Control Studies
  • Cohort Studies
  • Europe / epidemiology
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Genotype
  • High-Temperature Requirement A Serine Peptidase 1
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Odds Ratio
  • Polymorphism, Single Nucleotide*
  • Serine Endopeptidases / genetics*

Substances

  • High-Temperature Requirement A Serine Peptidase 1
  • HTRA1 protein, human
  • Serine Endopeptidases