Abstract
A new nor-cardenolide, named toxicarioside H (1), was isolated from the latex of Antiaris toxicaria (Pers.) Lesch (Moraceae). Its structure was elucidated on the basis of HRFAB-MS and spectroscopic techniques (IR, UV, 1D and 2D NMR). Compound 1 showed significant cytotoxicity against K562, SGC-7901, SMMC-7721, and HeLa cell lines in vitro by MTT method.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antiaris / chemistry*
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Cardenolides / isolation & purification*
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Cardenolides / pharmacology*
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Cardiac Glycosides / isolation & purification*
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Cardiac Glycosides / pharmacology*
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Cell Death / drug effects
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Cell Line, Tumor
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Humans
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Latex / chemistry*
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Magnetic Resonance Spectroscopy
Substances
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Cardenolides
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Cardiac Glycosides
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Latex
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toxicarioside H