Rapid development of hypertension by sorafenib: toxicity or target?

Clin Cancer Res. 2009 Oct 1;15(19):5947-9. doi: 10.1158/1078-0432.CCR-09-1717. Epub 2009 Sep 29.

Abstract

Blood pressure elevation is likely a pharmacodynamic marker of VEGF signaling pathway (VSP) inhibition and could be useful for optimizing safe and effective VSP inhibitor dosing. Blood pressure rises on the first day of treatment, facilitating design and interpretation of future trials aiming to correlate blood pressure changes with clinical outcomes.

Publication types

  • Comment

MeSH terms

  • Angiogenesis Inhibitors / administration & dosage
  • Angiogenesis Inhibitors / adverse effects
  • Angiogenesis Inhibitors / therapeutic use
  • Animals
  • Benzenesulfonates / administration & dosage
  • Benzenesulfonates / adverse effects*
  • Benzenesulfonates / therapeutic use
  • Blood Pressure / drug effects
  • Drug Delivery Systems / adverse effects
  • Drug Dosage Calculations
  • Drug-Related Side Effects and Adverse Reactions / etiology
  • Humans
  • Hypertension / chemically induced*
  • Mice
  • Models, Biological
  • Neoplasms / blood supply
  • Neoplasms / drug therapy
  • Neoplasms / physiopathology
  • Niacinamide / analogs & derivatives
  • Phenylurea Compounds
  • Pyridines / administration & dosage
  • Pyridines / adverse effects*
  • Pyridines / therapeutic use
  • Sorafenib
  • Treatment Outcome
  • Vascular Endothelial Growth Factor A / antagonists & inhibitors
  • Vascular Endothelial Growth Factor A / physiology

Substances

  • Angiogenesis Inhibitors
  • Benzenesulfonates
  • Phenylurea Compounds
  • Pyridines
  • VEGFA protein, human
  • Vascular Endothelial Growth Factor A
  • Niacinamide
  • Sorafenib