Correlation of high and decreased NY-ESO-1 immunity to spontaneous regression and subsequent recurrence in a lung cancer patient

Cancer Immun. 2009 Oct 1:9:8.

Abstract

We show correlation between strong and decreased NY-ESO-1-specific immunity with spontaneous regression and subsequent recurrence, respectively, in a long-surviving patient with an NY-ESO-1-expressing lung adenocarcinoma. An integrated immune response consisting of IgG antibody, as well as CD4 and CD8 T cells, against NY-ESO-1 was observed at the time of spontaneous regression of multiple pleural metastases. After tumor dormancy for 3 years, the tumor started to progress. IgG antibody levels and the number of CD4 and CD8 T cells against NY-ESO-1 decreased, but were still detectable. On the other hand, the number of Foxp3+ CD25 high T regulatory cells gradually increased. The findings suggest the relevance of the NY-ESO-1 immune response and its regulation by Foxp3+ CD25 high T regulatory cells in the clinical course of this lung cancer patient.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / immunology*
  • Adenocarcinoma / metabolism
  • Adenocarcinoma / physiopathology
  • Adenocarcinoma / secondary
  • Aged
  • Antigens, Neoplasm / genetics
  • Antigens, Neoplasm / immunology*
  • Antigens, Neoplasm / metabolism
  • CD4-Positive T-Lymphocytes / immunology
  • CD4-Positive T-Lymphocytes / metabolism
  • CD4-Positive T-Lymphocytes / pathology
  • CD8-Positive T-Lymphocytes / immunology
  • CD8-Positive T-Lymphocytes / metabolism
  • CD8-Positive T-Lymphocytes / pathology
  • Epitopes
  • Forkhead Transcription Factors / biosynthesis
  • Humans
  • Immunity*
  • Immunoglobulin G / metabolism
  • Interleukin-2 Receptor alpha Subunit / biosynthesis
  • Lung Neoplasms / immunology*
  • Lung Neoplasms / metabolism
  • Lung Neoplasms / pathology
  • Lung Neoplasms / physiopathology
  • Male
  • Membrane Proteins / genetics
  • Membrane Proteins / immunology*
  • Membrane Proteins / metabolism
  • Neoplasm Recurrence, Local
  • Neoplasm Regression, Spontaneous / immunology*
  • Pleural Neoplasms / immunology*
  • Pleural Neoplasms / metabolism
  • Pleural Neoplasms / physiopathology
  • Pleural Neoplasms / secondary
  • T-Cell Antigen Receptor Specificity
  • T-Lymphocytes, Regulatory / immunology
  • T-Lymphocytes, Regulatory / metabolism
  • T-Lymphocytes, Regulatory / pathology

Substances

  • Antigens, Neoplasm
  • CTAG1B protein, human
  • Epitopes
  • FOXP3 protein, human
  • Forkhead Transcription Factors
  • Immunoglobulin G
  • Interleukin-2 Receptor alpha Subunit
  • Membrane Proteins