Abstract
B cell lymphoma/leukemia gene 6 (Bcl6) is well known as a master regulator of germinal center (GC) B cell differentiation. Now, three new publications demonstrate that Bcl6 also plays a second role in GC response, in that it is both required and sufficient to drive the differentiation of T follicular helper cells.
MeSH terms
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Animals
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B-Lymphocytes / cytology
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B-Lymphocytes / immunology
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Cell Differentiation*
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / immunology*
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Germinal Center / cytology
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Germinal Center / immunology
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Humans
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Mice
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Proto-Oncogene Proteins c-bcl-6
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T-Lymphocytes, Helper-Inducer / cytology*
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T-Lymphocytes, Helper-Inducer / immunology
Substances
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BCL6 protein, human
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Bcl6 protein, mouse
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DNA-Binding Proteins
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Proto-Oncogene Proteins c-bcl-6