Asymmetric synthesis of the C7-C23 fragment of iriomoteolide-1a

Jun Xie; Yuelong Ma; David A Horne

doi:10.1021/ol902110a

Asymmetric synthesis of the C7-C23 fragment of iriomoteolide-1a

Org Lett. 2009 Nov 5;11(21):5082-4. doi: 10.1021/ol902110a.

Authors

Jun Xie¹, Yuelong Ma, David A Horne

Affiliation

¹ Department of Molecular Medicine, Beckman Research Institute at City of Hope, Duarte, California 91010, USA.

PMID: 19799392
DOI: 10.1021/ol902110a

Abstract

An efficient synthesis of the C(7)-C(23) fragment 2 of iriomoteolide-1a (1) has been accomplished via a B-alkyl Suzuki-Miyaura cross-coupling reaction followed by deprotection and cyclization to form the cyclic hemiketal core.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Cyclization
Dinoflagellida / chemistry
Macrolides / chemical synthesis*
Macrolides / chemistry
Molecular Structure

Substances

Macrolides
iriomoteolide-1a