Beta-globin gene haplotypes in Polynesians are predominantly southern Chinese in type

Hum Hered. 1990;40(5):285-9. doi: 10.1159/000153946.

Abstract

beta-Globin gene haplotypes obtained in Polynesian Samoans were similar to those described in Southern Chinese. An atypical HindIII restriction fragment length polymorphism detected with pRK29, a 3' beta-globin gene probe, was present at a gene frequency of 7% in Samoans. Haplotype patterns suggest that this polymorphism may have arisen by 1 or 2 mutational events. DNA haplotypes derived from the beta-globin gene cluster confirm nuclear and mitochondrial DNA data that Polynesian precursor populations were East Asian in origin.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosomes, Human, Pair 11*
  • Consanguinity
  • Globins / genetics*
  • Haplotypes
  • Humans
  • Independent State of Samoa
  • Native Hawaiian or Other Pacific Islander
  • Polymorphism, Restriction Fragment Length
  • Restriction Mapping

Substances

  • Globins