The excitatory amino acid antagonist amino-phosphono-valeric acid (APV) provides protection against penicillin-induced epileptic activity in the rat

Epilepsy Res. 1990 Aug;6(3):249-51. doi: 10.1016/0920-1211(90)90080-f.

Abstract

The effects of intraperitoneal injection of 2-amino-5-phosphono-valeric acid (APV) on EEG-monitored penicillin-induced epileptic activity in rats were evaluated. A significant decrease in the frequency of spikes occurred with low APV dosages (10 and 20 mg/kg), while an almost complete disappearance of spike activity was observed at higher APV doses (40 and 160 mg/kg). Our data suggest that excitatory amino acids play a relevant role in penicillin-induced epileptic activity in rats.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2-Amino-5-phosphonovalerate / therapeutic use*
  • Animals
  • Electroencephalography / drug effects
  • Epilepsy / chemically induced
  • Epilepsy / drug therapy*
  • Male
  • Motor Activity / drug effects
  • Penicillins / antagonists & inhibitors
  • Rats
  • Rats, Inbred Strains

Substances

  • Penicillins
  • 2-Amino-5-phosphonovalerate