Abstract
The resistance mechanism of 49 Enterobacteriaceae isolates with decreased susceptibility to carbapenems collected from 2004 to 2008 at 16 teaching hospitals in China was investigated. Moderate- to high-level carbapenem resistance in most isolates was more closely associated with loss or decreased expression of both major porins combined with production of AmpC or extended-spectrum beta-lactamase enzymes, while KPC-2, IMP-4, and IMP-8 carbapenemase production may lead to a low to moderate level of carbapenem resistance in Enterobacteriaceae in China.
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Bacterial Outer Membrane Proteins / genetics
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Bacterial Outer Membrane Proteins / metabolism
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Bacterial Proteins / metabolism
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Carbapenems / pharmacology*
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China / epidemiology
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Cross Infection / epidemiology
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Cross Infection / microbiology*
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Drug Resistance, Bacterial* / genetics
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Electrophoresis, Gel, Pulsed-Field
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Enterobacteriaceae / drug effects*
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Enterobacteriaceae / genetics*
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Enterobacteriaceae Infections / microbiology*
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Genotype
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Integrons / genetics
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Microbial Sensitivity Tests
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Phenotype
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Population Surveillance
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Porins / pharmacology
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Reverse Transcriptase Polymerase Chain Reaction
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beta-Lactamases / metabolism
Substances
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Anti-Bacterial Agents
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Bacterial Outer Membrane Proteins
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Bacterial Proteins
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Carbapenems
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Porins
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AmpC beta-lactamases
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beta-Lactamases
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carbapenemase