Static and dynamic discharge properties of vestibular-nerve afferents in the mouse are affected by core body temperature

Exp Brain Res. 2010 Jan;200(3-4):269-75. doi: 10.1007/s00221-009-2015-y. Epub 2009 Oct 6.

Abstract

The goal of this study was to determine the effect of changes in core body temperature on the resting discharge rate and sensitivity of vestibular-nerve afferents. Extracellular recordings were made from vestibular-nerve afferents innervating the semicircular canals in anesthetized C57BL/6 mice maintained at a core body temperature of either 30-32 degrees C (T (31)) or 35-37 degrees C (T (36)). The resting rates of regular (CV* < 0.1) and irregular afferents (CV* > 0.1) were lower at T (31) than at T (36). Sensitivity and phase were compared for rotations ranging from 0.1 to 12 Hz by calculating coefficients of a transfer function, g . t(c)S . (t(z)S +1)/(t(c)S + 1), for each afferent. The sensitivity (g) increased with CV* and with higher core body temperature. The value of the coefficient representing the low-frequency dynamics (t (c)) varied inversely with CV* but did not change with core body temperature. The high-frequency dynamics represented by t (z) increased with CV* and decreased with higher core body temperature. These findings indicate that changes in temperature have effects on the static and dynamic properties of vestibular-nerve afferents.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Action Potentials / physiology*
  • Animals
  • Body Temperature / physiology*
  • Mice
  • Mice, Inbred C57BL
  • Neurons, Afferent / physiology*
  • Nonlinear Dynamics*
  • Regression Analysis
  • Rotation
  • Semicircular Canals / innervation
  • Vestibular Nerve / cytology*