Abstract
Here, we describe a case of an HIV-infected patient with right lower limb oedema that appeared after initiation of tenofovir and emtricitabine treatment. The patient was fully investigated by serial heart and vessel echo-Doppler examination. Oedema of the lower limb was attributed to a transient drug-induced fivefold increase in peripheral artery flow, which was induced by a reduction in peripheral arterial resistance. The possible mechanisms of disease are discussed.
MeSH terms
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Adenine / adverse effects
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Adenine / analogs & derivatives*
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Adenine / therapeutic use
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Adult
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Blood Flow Velocity / drug effects*
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Deoxycytidine / adverse effects
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Deoxycytidine / analogs & derivatives*
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Deoxycytidine / therapeutic use
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Edema / chemically induced
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Edema / pathology
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Emtricitabine
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HIV Infections / drug therapy
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Humans
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Leg / blood supply
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Male
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Organophosphonates / adverse effects*
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Organophosphonates / therapeutic use*
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Tenofovir
Substances
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Organophosphonates
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Deoxycytidine
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Tenofovir
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Emtricitabine
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Adenine