Abstract
Seven new inorganic heteropolyanions were tested for their antiviral activity. One of these, sodium 12-tungstoborate, was found to protect mice from Semliki forest virus and mouse embryo fibroblast monolayers from vaccinia virus infections. In mice these heteropolyanions exhibited no synergistic antiviral activity with the interferon inducing mycoviral double-stranded RNA.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antiviral Agents*
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Borates / pharmacology*
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Female
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Male
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Mice
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Polyelectrolytes
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Polymers / pharmacology*
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Semliki forest virus / drug effects*
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Semliki forest virus / growth & development
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Togaviridae Infections / prevention & control
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Tungsten / pharmacology*
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Tungsten Compounds*
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Vaccinia virus / drug effects*
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Vaccinia virus / growth & development
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Viral Plaque Assay
Substances
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Antiviral Agents
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Borates
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Polyelectrolytes
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Polymers
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Tungsten Compounds
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polyanions
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12-tungstoborate
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Tungsten