Therapeutic vaccination and novel strategies to treat chronic HBV infection

Expert Rev Gastroenterol Hepatol. 2009 Oct;3(5):561-9. doi: 10.1586/egh.09.48.

Abstract

Therapeutic vaccination for the treatment of chronic hepatitis B has so far shown limited clinical efficacy. In this review, we argue that the principal cause of this failure is the profound defect of virus-specific T cells present in chronic hepatitis B patients and we discuss potential new ways to achieve an efficient restoration of virus-specific immunity in patients with chronic hepatitis B virus infection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Hepatitis B Vaccines / therapeutic use*
  • Hepatitis B virus / immunology*
  • Hepatitis B, Chronic / immunology
  • Hepatitis B, Chronic / therapy*
  • Humans
  • Immunity, Innate*
  • T-Lymphocyte Subsets / immunology*
  • T-Lymphocyte Subsets / virology
  • Treatment Failure
  • Treatment Outcome

Substances

  • Hepatitis B Vaccines