Abstract
A series of dialkylphosphocholines were prepared and evaluated for their biological activity. The antiprotozoal activity was determined against Acanthamoeba lugdunensis. Compound 15 exhibited excellent trophocidal activity. None of the tested dialkylphosphocholines exhibited better fungicidal activity against Candida albicans than miltefosine. The antineoplastic activity was determined against HeLa. The most cytotoxic was compound 10, which was more active against tumor cells as against normal cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acanthamoeba
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Anti-Bacterial Agents / pharmacology
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / pharmacology
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Antineoplastic Agents / pharmacology*
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Antiprotozoal Agents
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Candida albicans / drug effects
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Drug Screening Assays, Antitumor
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Inhibitory Concentration 50
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Microbial Sensitivity Tests*
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Molecular Structure
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Phosphorylcholine / analogs & derivatives
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Plant Extracts
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Antineoplastic Agents
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Antiprotozoal Agents
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Plant Extracts
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Phosphorylcholine
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miltefosine