Executive functions in the absence of behavior: functional imaging of the minimally conscious state

Prog Brain Res. 2009:177:249-60. doi: 10.1016/S0079-6123(09)17717-8.

Abstract

One of the major challenges in the clinical evaluation of brain injury survivors is to comprehensively assess the level of preserved cognitive function in order to inform diagnostic decisions and suggest appropriate rehabilitation strategies. However, the limited (if any) capacity for producing behavior in some of these patients often limits the extent to which cognitive functions can be explored via standard bedside methods. We present a novel neuroimaging paradigm that allows the assessment of residual executive functions without requiring the patient to produce any behavioral output. In particular, we target processes such as active maintenance of information through time and willful adoption of "mind-sets" that have been proposed to require conscious awareness. Employing an fMRI block design paradigm, healthy volunteers were presented with a series of neutral (i.e., not emotionally salient) words, and alternatively instructed to listen to all the words, or to count the number of times a given target is repeated. Importantly, the perceptual stimulation in the passive listening and the counting tasks was carefully matched. Contrasted with passive listening, the counting task revealed a fronto-parietal network previously associated with target detection and working memory. Remarkably, when tested on this same procedure, a minimally conscious patient presented a highly similar pattern of activation. Furthermore, the activity in these regions appeared highly synchronous to the onset and offset of the counting blocks. Considering the close matching of sensory stimulation across the two tasks, these findings strongly suggest that the patient could willfully adopt differential "mind-sets" as a function of condition, and could actively maintain information across time. Neither cognitive function was apparent when the patient was (behaviorally) tested at the bedside. This paradigm thus exemplifies the potential for fMRI to explore high-level cognitive functions, and awareness, in the absence of any behavioral response.

MeSH terms

  • Acoustic Stimulation / methods
  • Auditory Perception / physiology
  • Brain / blood supply*
  • Brain / physiopathology
  • Brain Mapping*
  • Executive Function / physiology*
  • Female
  • Functional Laterality
  • Humans
  • Image Processing, Computer-Assisted / methods
  • Magnetic Resonance Imaging / methods
  • Male
  • Neuropsychological Tests
  • Oxygen / blood
  • Persistent Vegetative State / diagnosis*
  • Persistent Vegetative State / physiopathology*
  • Reaction Time / physiology
  • Retrospective Studies
  • Time Factors
  • Vocabulary

Substances

  • Oxygen