Abstract
Arginine-pyrimidine conjugates represent a novel class of compounds that exhibits therapeutic and prophylactic activity in lethal infections by Gram-positive and Gram-negative bacteria without showing antibacterial activity in vitro.
MeSH terms
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Animals
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Anti-Bacterial Agents / pharmacology*
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Anti-Bacterial Agents / therapeutic use
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Arginine / chemistry
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Arginine / pharmacology*
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Bacterial Infections / drug therapy
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Cross Infection / drug therapy*
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Drug Interactions
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Drug Resistance, Multiple, Bacterial
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Gram-Negative Bacteria / drug effects
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Methicillin Resistance
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Mice
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Mice, Inbred ICR
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Microbial Sensitivity Tests*
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Pyrimidines / chemistry
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Pyrimidines / pharmacology*
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Streptococcal Infections / drug therapy
Substances
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Anti-Bacterial Agents
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Pyrimidines
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Arginine