Genotypes, superantigen gene profiles, and presence of exfoliative toxin genes in clinical methicillin-susceptible Staphylococcus aureus isolates

Marijke J C A van Trijp; Damian C Melles; Susan V Snijders; Heiman F L Wertheim; Henri A Verbrugh; Alex van Belkum; Willem J van Wamel

doi:10.1016/j.diagmicrobio.2009.08.021

Genotypes, superantigen gene profiles, and presence of exfoliative toxin genes in clinical methicillin-susceptible Staphylococcus aureus isolates

Diagn Microbiol Infect Dis. 2010 Feb;66(2):222-4. doi: 10.1016/j.diagmicrobio.2009.08.021. Epub 2009 Oct 13.

Authors

Marijke J C A van Trijp¹, Damian C Melles, Susan V Snijders, Heiman F L Wertheim, Henri A Verbrugh, Alex van Belkum, Willem J van Wamel

Affiliation

¹ Maasstad Hospital, HT Rotterdam, The Netherlands. [email protected]

PMID: 19828275
DOI: 10.1016/j.diagmicrobio.2009.08.021

Abstract

We compared genotype and virulence gene profiles for strains from carriers with autologous invasive infection (n = 56), nasal isolates from matched carriers (n = 108), and invasive strains from noncarriers (n = 34). Superantigen gene profiles and presence of exfoliative toxin genes A and D were associated with clonal complex rather than with invasive disease.

MeSH terms

Adult
Aged
Aged, 80 and over
Antigens, Bacterial / genetics*
Bacterial Proteins / genetics
Carrier State / microbiology
DNA Fingerprinting
DNA, Bacterial / genetics
Exfoliatins / genetics*
Female
Genotype
Humans
Male
Middle Aged
Staphylococcal Infections / microbiology*
Staphylococcus aureus / genetics*
Staphylococcus aureus / isolation & purification
Superantigens / genetics*
Virulence Factors / genetics

Substances

Antigens, Bacterial
Bacterial Proteins
DNA, Bacterial
Exfoliatins
Superantigens
Virulence Factors