Abstract
The aldol reactions of alpha-keto phosphonates and aldehydes were facilitated by an axially chiral biphenylprolinamide under mild conditions, affording the synthetically and pharmaceutically useful products in high yields and excellent enantioselectivities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aldehydes / chemistry
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Anilides / chemistry*
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Biphenyl Compounds / chemistry*
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Catalysis
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Organophosphonates / chemical synthesis*
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Organophosphonates / chemistry*
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Proline / chemistry
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Stereoisomerism
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Substrate Specificity
Substances
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Aldehydes
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Anilides
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Biphenyl Compounds
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Organophosphonates
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3-hydroxybutanal
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Proline