Abstract
Modulation of smooth muscle cells to a proliferating and migrating phenotype with downregulated alpha-actin expression is observed upon vascular lesion formation. The Id proteins (inhibitors of cell differentiation) play a role in the development of this phenotype. In contrast, synthetic peptides based on a conserved 11-residue Id sequence trigger the switch to a contractile phenotype that shows reduced cell growth and migration, increased expression of alpha-actin and decreased Id protein levels.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Actins / physiology
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Amino Acid Motifs / physiology*
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Aorta, Thoracic
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Calcium-Binding Proteins
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Cell Differentiation / physiology*
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Cell Proliferation*
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Conserved Sequence / physiology*
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Endothelium, Vascular / cytology
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Inhibitor of Differentiation Proteins / genetics
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Inhibitor of Differentiation Proteins / physiology*
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Muscle, Smooth, Vascular / physiology*
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Myocytes, Smooth Muscle / cytology
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Myocytes, Smooth Muscle / physiology
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Nuclear Proteins
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Peptides / chemical synthesis
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Peptides / physiology*
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Phenotype
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Protein Binding
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Repressor Proteins
Substances
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Actins
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Calcium-Binding Proteins
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Inhibitor of Differentiation Proteins
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Nuclear Proteins
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Peptides
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Repressor Proteins