Abstract
An investigation of the constituents in heartwood and resin of Prunus avium is reported. A mini-library of structurally diverse flavanones and flavones was screened for human cytochrome P450 1A1, 3A4 and 19 (aromatase) inhibition, and for antifungal activity against a panel of pathogenic fungi. The defensive role of these natural plant flavonoids as antifungal phytoalexins and phytoanticipins is discussed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology*
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Cytochrome P-450 Enzyme Inhibitors*
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Flavanones / isolation & purification
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Flavanones / pharmacology*
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Flavones / isolation & purification
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Flavones / pharmacology*
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Fungi / drug effects*
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Fungi / pathogenicity
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Phytoalexins
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Prunus / chemistry*
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Resins, Plant / chemistry*
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Sesquiterpenes
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Terpenes / isolation & purification
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Terpenes / pharmacology*
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Wood / chemistry*
Substances
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Antifungal Agents
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Cytochrome P-450 Enzyme Inhibitors
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Flavanones
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Flavones
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Resins, Plant
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Sesquiterpenes
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Terpenes
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Phytoalexins