Abstract
Two new jaspamide derivatives 2 and 3, together with the parent compound jaspamide (1) have been isolated from the marine sponge Jaspis splendens collected in Kalimantan (Indonesia). The structures of the new compounds were unambiguously elucidated based on 1D and 2D NMR spectral data, mass spectrometry and comparison with jaspamide (1). The new derivatives inhibited the growth of mouse lymphoma (L5178Y) cell line in vitro with IC(50) values of <0.1 microg/mL.
Keywords:
Jaspis splendens; cytotoxic activity; jaspamide Q and R; structure elucidation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Depsipeptides / chemistry
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Depsipeptides / isolation & purification
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Depsipeptides / pharmacology*
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Drug Screening Assays, Antitumor
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Indonesia
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Inhibitory Concentration 50
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Lymphoma / drug therapy*
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Magnetic Resonance Spectroscopy / methods
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Mass Spectrometry
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Mice
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Porifera / chemistry*
Substances
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Antineoplastic Agents
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Depsipeptides
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jaspamide Q
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jaspamide R
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jasplakinolide