Abstract
A new cyclic diamine, 1,5-diazacyclohenicosane (1), was isolated from samples of the marine sponge Mycale sp. collected at Lamu Island (Kenya). Its structure was determined by a combination of spectroscopic techniques, including (+)-HRESIMS and 1D and 2D NMR spectroscopy. The compound displayed cytotoxicity at the muM level against three human tumor cell lines.
Keywords:
Mycale sp; alkaloids; cytotoxicity; marine sponges.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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Heterocyclic Compounds, 1-Ring / isolation & purification
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Heterocyclic Compounds, 1-Ring / pharmacology*
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Humans
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Kenya
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Porifera / chemistry*
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Spectrum Analysis / methods
Substances
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1,5-diazacyclohenicosane
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Antineoplastic Agents
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Heterocyclic Compounds, 1-Ring