Ursodeoxycholic acid's role in avoiding diversionary surgery in idiopathic fibrosing pancreatitis

J Paediatr Child Health. 2009 Nov;45(11):681-3. doi: 10.1111/j.1440-1754.2009.01595.x. Epub 2009 Oct 19.

Abstract

Obstructive jaundice in childhood is rare but a cause of great concern and warrants aggressive investigation into its aetiology. Idiopathic fibrosing pancreatitis (IFP) is a rare cause of this phenomenon and is presently a diagnosis of exclusion with lymphoma a main differential diagnosis. IFP appears to be a self limiting occurrence and as a result the previous gold standard of therapy of surgical diversion may ultimately be unnecessary. We describe ursodeoxycholic acid as a useful adjunct to treatment allowing more time for clinicians to evaluate the nature of the underlying disease process without hastily moving towards invasive surgery until clearly indicated.

Publication types

  • Case Reports

MeSH terms

  • Child, Preschool
  • Cholagogues and Choleretics / therapeutic use
  • Cholestasis / diagnosis
  • Cholestasis / drug therapy
  • Cholestasis / etiology*
  • Diagnosis, Differential
  • Female
  • Fibrosis
  • Humans
  • Jaundice, Obstructive / diagnosis
  • Jaundice, Obstructive / drug therapy
  • Jaundice, Obstructive / etiology*
  • Pancreatitis / complications*
  • Pancreatitis / drug therapy
  • Pancreatitis / pathology
  • Pancreatitis / surgery
  • Positron-Emission Tomography
  • Ursodeoxycholic Acid / administration & dosage
  • Ursodeoxycholic Acid / therapeutic use*
  • Victoria

Substances

  • Cholagogues and Choleretics
  • Ursodeoxycholic Acid