Abstract
We report a patient with microbiologically documented tuberculous meningitis showing that the therapeutic paradox, a therapy-induced switch to a neutrophil-predominant situation in the differential cell counts of cerebrospinal fluid specimens, had a correlation with an immunologic paradox, an increased Mycobacterium tuberculosis-specific gamma interferon-producing T-cell response.
MeSH terms
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Adult
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Cell Count
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Diagnosis, Differential
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Female
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Humans
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Interferon-gamma / immunology*
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Interleukin-8 / biosynthesis
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Interleukin-8 / immunology
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Mycobacterium tuberculosis / immunology*
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T-Lymphocytes / immunology*
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Tuberculosis, Meningeal / cerebrospinal fluid
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Tuberculosis, Meningeal / diagnosis*
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Tuberculosis, Meningeal / immunology
Substances
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Interleukin-8
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Interferon-gamma