Reciprocal translocation involving 3q21 in an unusual myeloproliferative disorder with myelodysplastic features and prominent dysmegakaryopoiesis

M Cedrone; C Mecucci; V L Burgio; D Diverio; M C Petti; G Alimena

doi:10.1016/0165-4608(91)90011-i

Reciprocal translocation involving 3q21 in an unusual myeloproliferative disorder with myelodysplastic features and prominent dysmegakaryopoiesis

Cancer Genet Cytogenet. 1991 Jan;51(1):73-8. doi: 10.1016/0165-4608(91)90011-i.

Authors

M Cedrone¹, C Mecucci, V L Burgio, D Diverio, M C Petti, G Alimena

Affiliation

¹ Department of Human Biopathology, University of Rome La Sapienza, Italy.

PMID: 1984850
DOI: 10.1016/0165-4608(91)90011-i

Abstract

A case with an atypical myeloproliferative disorder (MPD) characterized by overt dysmyelopoiesis, mostly represented by abnormal thrombopoiesis and showing a t(3;18)(q21;q21), is described. The unusual hematological findings, which characterized a disease borderline between two distinct entities, namely MPD and myelodysplastic syndromes, are also discussed in relation to the cytogenetic abnormality affecting region 3q21 and possibly dictating the abnormal thrombopoiesis.

Publication types

Case Reports
Research Support, Non-U.S. Gov't
Review

MeSH terms

Aged
Bone Marrow / pathology
Chromosomes, Human, Pair 3*
Humans
Karyotyping
Male
Megakaryocytes / pathology
Myelodysplastic Syndromes / complications
Myelodysplastic Syndromes / genetics
Myeloproliferative Disorders / genetics*
Translocation, Genetic*