This supplement highlights key talks presented at the Pennington Symposium. The collected papers provide a state of the art review of circadian biology at the basic and clinical levels in the context of nutrition, obesity and sleep medicine. Investigators from multiple disciplines attempted to translate new information concerning molecular mechanisms into practical clinical applications, as well as foster new research hypotheses and directions to this exciting field of science and medicine. Furthermore, we hope to spark the interest and attention of the next generation of scientists who will tackle the questions presented by the changing interface between technology, lifestyle and biological rhythms.